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ea0029p1789 | Thyroid cancer | ICEECE2012

The occurrence of mutations in the CHEK2 gene in patients with papillary thyroid carcinoma and its impact on the course of the disease and the coexistence of other neoplasms

Kowalska A. , Gasior-Perczak D. , Palyga I. , Siolek M. , Kozak-Klonowska B. , Kowalik A. , Lubinski J. , Cybulski C. , Mezyk R. , Gozdz S.

Introduction: CHEK2 is a gene encoding a protein involved in the mechanism of repairing damaged DNA. Mutations in the CHEK2 gene are associated with an increased risk of various neoplasms. The most common mutations in the Polish population are: I157T, less frequently IVS2+1G> A and 1100delC.Materials: The study consisted of 277 patients with papillary thyroid carcinoma: 252 female, 25 male, aged 15 to 76 years.Method: Patients ...

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ea0029p492 | Developmental endocrinology | ICEECE2012

Oestradiol and its biochemical precursor levels decline in men around the age of their late twenties, what may determine the conclusion of bone maturation

Szyska-Skrobot D. , Slowikowska-Hilczer J. , Walczak-Jedrzejowska R. , Kula P. , Marchlewska K. , Oszukowska E. , Filipiak E. , Mezyk R. , Kowalska A. , Kula K.

Introduction: Longitudinal bone growth ceases by the end of puberty, and the induction of epiphyseal maturation and closure is thought to be a result in both sexes of the action of increased pubertal oestrogen concentrations. However, bone mass accrual progresses beyond puberty and we related sex steroid hormones and sex hormone binding globulin (SHBG) levels to calcaneal quantitative ultrasound index (QUI) in young adult men.Methods: Eighty men aged bet...

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Endocrine Abstracts

The occurrence of mutations in the CHEK2 gene in patients with papillary thyroid carcinoma and its impact on the course of the disease and the coexistence of other neoplasms

Oestradiol and its biochemical precursor levels decline in men around the age of their late twenties, what may determine the conclusion of bone maturation

BiosciAbstracts